The $43B Big Pharma Story is Starting Over-With a New Player

Big Pharma once paid $43B for a small biotech with a similar platform. Now, a new company is following that same playbook, leveraging its patented delivery technology to attract partnerships and near-term revenue potential.

AP Business News Digest

JOVANA GEC
November 07, 2025

Here are the AP's top business stories that have moved or are planned to move today. All times U.S. Eastern. For up-to-the minute information on AP's coverage, visit AP Newsroom's Coverage Plan.

Financial Markets

World shares retreat after falling tech stocks pull Wall Street lower

SUMMARY: Shares have declined in Europe and Asia after losses for influential technology stocks pulled Wall Street benchmarks lower. U.S. futures have advanced and oil prices are also higher. China reported that its exports contracted 1.1% in October, as shipments to the United States dropped by 25% from a year earlier. But economists expect Chinese exports to recover after U.S. President Donald Trump and Chinese leader Xi Jinping agreed last week to de-escalate the trade war between the two largest economies. On Thursday, the S&P 500 fell 1.1% and the Dow industrials lost 0.8%. The Nasdaq composite sank 1.9%.

WORDS: 659 - MOVED: 11/07/2025 1:04 a.m. EST

https://newsroom.ap.org/detail/WorldsharesretreatafterfallingtechstockspullWallStreetlower/e50166021211dde65703d637c2889f2b/text

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US--Economy-No Hiring

'No hire' job market leaves unemployed in limbo as threats to economy multiply

SUMMARY: The unemployment rate is low and the economy is still growing, but those out of work face the slowest pace of hiring in more than a decade. While big corporate layoff announcements typically grab the most attention, it has been the unwillingness of many companies to add workers that has created a more painful job market than the low 4.3% unemployment rate would suggest. It is also more bifurcated: The "low hire, low fire" economy has meant fewer layoffs for those with jobs, while the unemployed struggle to find work.

WORDS: 1186 - MOVED: 11/06/2025 5:47 p.m. EST

https://newsroom.ap.org/detail/Nohirejobmarketleavesunemployedinlimboasthreatstoeconomymultiply/c48fd84dfaa71eee962feb3a88fd8575/text

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EU--Switzerland-US-Gunvor-Lukoil

Trading firm Gunvor, accused by US of being 'Kremlin's puppet,' drops plan to buy Lukoil assets

SUMMARY: Gunvor, a major international commodities trader, has rejected U.S. government claims that it acts as "the Kremlin's puppet." The company announced it is dropping plans to buy the international operations of Russian oil company Lukoil. Gunvor, based in Geneva, made the announcement on X, formerly known as Twitter. The U.S. Treasury Department had linked Gunvor to Russian President Vladimir Putin's actions in Ukraine. Gunvor responded by stating that the Treasury's claims are "fundamentally misinformed and false." The company emphasized its transparency and noted steps it took to distance itself from Russia over the past decade.

WORDS: 405 - MOVED: 11/07/2025 5:37 a.m. EST

https://newsroom.ap.org/detail/TradingfirmGunvoraccusedbyUSofbeingKremlinspuppetdropsplantobuyLukoilassets/4664b2a87135b8960dedf0ad463ee4f5/text

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AS--Japan-Earns-Honda

Honda's profit slips as President Trump's tariffs take their toll on Japanese automakers

SUMMARY: Honda has reported a 37% drop in profit for the first fiscal half through September. The impact of tariffs from President Donald Trump and unfavorable currency rates offset strong motorcycle sales. Honda's profit for April to September was 311.8 billion yen ($2 billion), down from 494.6 billion yen the previous year. The company has lowered its profit forecast for the fiscal year through March 2026 to 300 billion yen, a 64% decline from the previous year. Despite challenges, Honda achieved record motorcycle sales in Asia. However, a chip shortage has disrupted vehicle production in Mexico and North America.

WORDS: 434 - MOVED: 11/07/2025 3:35 a.m. EST

https://newsroom.ap.org/detail/HondasprofitslipsasPresidentTrumpstariffstaketheirtollonJapaneseautomakers/a4cbb907a78e64819c0d65f36e11775d/text

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US--Trump-Obesity Drugs

Trump unveils deal to expand coverage and lower costs on obesity drugs

SUMMARY: President Donald Trump has unveiled a deal with drugmakers Eli Lilly and Novo Nordisk to expand coverage and reduce prices for their popular obesity treatments Zepbound and Wegovy.  The drugs are part of a new generation of obesity medications known as GLP-1 receptor agonists that have soared in popularity in recent years. But access to the drugs has been a consistent problem for patients because of their cost and spotty insurance coverage. Thursday's announcement is the latest attempt by the Trump administration to rein in soaring drug prices in its efforts to address cost-of-living concerns among voters.

WORDS: 1173 - MOVED: 11/06/2025 12:06 p.m. EST

https://newsroom.ap.org/detail/Trumpunveilsdealtoexpandcoverageandlowercostsonobesitydrugs/15b24e03d558aa6bbcf37e52ba2d354e/text

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US--OpenAI-Lawsuits

OpenAI faces 7 lawsuits claiming ChatGPT drove people to suicide, delusions

SUMMARY: OpenAI is facing seven lawsuits claiming ChatGPT drove people to suicide and harmful delusions even when they had no prior mental health issues. The lawsuits filed Thursday in California state courts allege wrongful death, assisted suicide, involuntary manslaughter and negligence. Filed on behalf of six adults and one teenager by the Social Media Victims Law Center and Tech Justice Law Project, the lawsuits claim that OpenAI knowingly released GPT-4o prematurely, despite internal warnings that it was dangerously sycophantic and psychologically manipulative. Four of the victims died by suicide. OpenAI said it is reviewing the lawsuits.

WORDS: 510 - MOVED: 11/06/2025 8:18 p.m. EST

https://newsroom.ap.org/detail/OpenAIfaceslawsuitsclaimingChatGPTdrovepeopletosuicidedelusions/56e63e5538602ea39116f1904bf7cdc3/text

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US-Musk-Pay Package

Musk could become history's first trillionaire as Tesla shareholders approve giant pay package

SUMMARY: The world's richest man was just handed a chance to become history's first trillionaire. Elon Musk won a shareholder vote on Thursday that would give the Tesla CEO stock worth $1 trillion if he hits certain performance targets over the next decade. The vote followed weeks of debate over his management record and whether anyone deserved such unprecedented pay, drawing heated commentary from small investors to giant pension funds and even the pope. It was a resounding victory for Musk, showing that investors still have faith in him as the car company struggles with plunging sales and profits.

WORDS: 882 - MOVED: 11/06/2025 5:06 p.m. EST

https://newsroom.ap.org/detail/MuskcouldbecomehistorysfirsttrillionaireasTeslashareholdersapprovegiantpaypackage/f2140db92e8032121f4c114234059165/text

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US--Philanthropy-Shaggy Jamaica

Shaggy recounts his relief mission to Jamaica after Hurricane Melissa and shares how you can help

SUMMARY: Shaggy, the Grammy-winning reggae artist, has stepped up to help Jamaica following Hurricane Melissa. He used ChatGPT to determine what supplies were needed and quickly organized relief efforts. The Kingston-based "Boombastic" hitmaker mobilized supplies from Miami and personally delivered them to the hardest-hit areas. He emphasizes the urgency of raising awareness about Jamaica's needs, saying the country has been forever changed by the storm. Shaggy is working with organizations like Global Empowerment Mission to ensure aid reaches those in need.

WORDS: 914 - MOVED: 11/06/2025 6:59 p.m. EST

https://newsroom.ap.org/detail/ShaggyrecountshisreliefmissiontoJamaicaafterHurricaneMelissaandshareshowyoucanhelp/24c4481b85e14e23b2ca9d07fde22860/text

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Financial Markets

Wall Street loses ground under the weight of falling technology stocks

SUMMARY: Wall Street lost ground as influential technology stocks fell and once again steered the broader market. The S&P 500 fell 1.1% Thursday. The Dow Jones Industrial Average fell 0.8%, and the Nasdaq composite lost 1.9%. DoorDash sank after warning investors that it will be spending much more on product development next year. CarMax lost almost a quarter of its value after forecasting earnings far below what analysts were expecting and announcing that its CEO is leaving. European markets fell after a divided Bank of England kept its main interest rate unchanged. Asian markets closed higher. Treasury yields fell.

WORDS: 842 - MOVED: 11/06/2025 12:43 a.m. EST

https://newsroom.ap.org/detail/WallStreetlosesgroundundertheweightoffallingtechnologystocks/2bbca7be90e3bde0a001904329d23641/text

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Financial Markets-Box

How major US stock indexes fared Thursday, 11/6/2025

SUMMARY: Stocks closed lower on Wall Street, pulled down by more losses in big technology stocks. The S&P 500 fell 1.1% Thursday. The Dow Jones Industrial Average fell 0.8%, and the Nasdaq composite lost 1.9%. DoorDash sank after warning investors that it will be spending much more on product development next year. CarMax lost almost a quarter of its value after forecasting earnings far below what analysts were expecting and announcing that its CEO is leaving.

WORDS: 239 - MOVED: 11/06/2025 4:25 p.m. EST

https://newsroom.ap.org/detail/HowmajorUSstockindexesfaredThursday/51d8dd86310939070c82b2056a06389f/text

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US-EEOC Chair-Andrea Lucas

Trump taps DEI critic to lead workplace civil rights agency

SUMMARY: President Donald Trump has appointed Andrea Lucas as chair of the nation's top workplace civil rights agency. This move shows support for Lucas's efforts to root out diversity programs and roll back protections for transgender workers. Lucas was first nominated to the U.S. Equal Employment Opportunity Commission in 2020. Her confirmation faced strong opposition from Democratic lawmakers and civil rights groups. They accused her of politicizing the agency. Republican senators praised her leadership, especially her commitment to reversing Biden-era guidance on gender identity protections. Lucas has focused on religious discrimination cases and has dropped lawsuits supporting transgender workers.

WORDS: 738 - MOVED: 11/06/2025 1:25 p.m. EST

https://newsroom.ap.org/detail/TrumptapsDEIcritictoleadworkplacecivilrightsagency/591b48113bf6fab1a17d84e58cf9ac8f/text

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US-Holiday Spending

National Retail Federation predicts first $1 trillion holiday shopping season

SUMMARY: American shoppers are expected to spend more during this holiday shopping season than last year despite economic uncertainty and rising prices. The 2025 forecast from the National Retail Federation on Thursday estimates that shoppers will collectively spend between $1.01 trillion and $1.02 trillion in November and December, an increase of 3.7% to 4.2% compared with last year. Retailers rung up $976 billion in holiday sales last year, the group said. The group's holiday forecast is based on economic modeling using various key economic indicators including consumer spending, disposable personal income, employment, wages, inflation and previous monthly retail sales releases. NRF's calculation excludes automobile dealers, gasoline stations and restaurants to focus on core retail.

WORDS: 753 - MOVED: 11/06/2025 11:24 a.m. EST

https://newsroom.ap.org/detail/NationalRetailFederationpredictsfirsttrillionholidayshoppingseason/de5b851a009fed78b446676c1d944853/text

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One Tech Tip-Stop Car Spying-Privacy

One Tech Tip: Modern cars are spying on you. Here's what you can do about it

SUMMARY: Modern cars are collecting more data than ever, raising privacy concerns. The Mozilla Foundation says cars are the worst product category for privacy. They collect data from interactions, onboard services, and connected devices. This data is often shared with insurers and data brokers. Drivers should be aware of what their car collects. Privacy4Cars offers a service to check automakers' data practices. Drivers can adjust settings to limit data sharing. Opting out may affect features like navigation and roadside assistance. When selling a car, a factory reset is recommended to protect personal data.

WORDS: 1080 - MOVED: 11/05/2025 6:15 p.m. EST

https://newsroom.ap.org/detail/OneTechTipModerncarsarespyingonyouHereswhatyoucandoaboutit/3674ce59c9b30f2861d29178a31e6ab7/text

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US--Government Shutdown-Travelers

Travelers brace for chaos as US government shutdown threatens holiday flights

SUMMARY: Travelers across the U.S. are facing potential chaos as a government shutdown threatens to disrupt flights nationwide. The Federal Aviation Administration has announced a reduction in air traffic at 40 airports starting Friday, causing concern for those with upcoming travel plans. This includes major hubs like Atlanta, Denver, and San Francisco. With Thanksgiving approaching, many are worried about cancellations and delays. Some travelers are opting to drive instead of risking flight issues. Others are booking backup reservations or finding alternative routes.

WORDS: 622 - MOVED: 11/06/2025 2:01 p.m. EST

https://newsroom.ap.org/detail/TravelersbraceforchaosasUSgovernmentshutdownthreatensholidayflights/523690be1f72b90b2a9e0676794f829d/text

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Mortgage Rates

Average US long-term mortgage rate ticks up to 6.22% after four straight weekly declines

SUMMARY: The average rate on a 30-year U.S. mortgage ticked up for the first time in five weeks after falling to its lowest level in more than a year last week. The average long-term mortgage rate moved up to 6.22% from 6.17% last week, mortgage buyer Freddie Mac said Thursday. A year ago, the rate averaged 6.79%. Last week's average rate the lowest since Oct. 3, 2024, when it was 6.12%. Borrowing costs on 15-year fixed-rate mortgages, popular with homeowners refinancing their home loans, also rose this week. The average rate rose to 5.5% from 5.41% last week. A year ago, it was 6%, Freddie Mac said.

WORDS: 568 - MOVED: 11/06/2025 12:05 p.m. EST

https://newsroom.ap.org/detail/AverageUSlongtermmortgagerateticksuptoafterfourstraightweeklydeclines/1b593f2df00d59aed59970d845c6b7cc/text

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EU-Britain-Economy

Divided Bank of England holds key interest rate at 4% despite hopes inflation has peaked

SUMMARY: The Bank of England has kept its main interest rate unchanged at 4% as inflation in the U.K. remains markedly above target and policymakers await this month's budget from the U.K. government, which could be one of the most consequential in years. Thursday's decision by the nine-member rate-setting body was widely anticipated, though some economists thought there was a chance that borrowing rates would be reduced by a further quarter of a percentage point. The main reason why rates were kept on hold is that the annual rate of consumer price inflation is standing at 3.8%, nearly double the bank's 2% target.

WORDS: 502 - MOVED: 11/06/2025 7:06 a.m. EST

https://newsroom.ap.org/detail/DividedBankofEnglandholdskeyinterestrateatdespitehopesinflationhaspeaked/f660c574e9dbb7092271968a3fd0608c/text

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<END>

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